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Apaf1 Antibody
Apaf1 Antibody
產品編號: 2013
規  格:
單  價: 詢價
生 產 商: ProSci
到貨時間: 2-3weeks
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BACKGROUND
Apaf1 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease-activating factor 1). Apaf1 binds to cytochrome c (Apaf-2) and caspase-9 (Apaf-3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf1 can also associate with caspase-4 and caspase-8. Apaf1 is ubiquitously expressed in human tissues.

ALTERNATE NAMES
Apaf1 Antibody: CED4, APAF-1, KIAA0413, Apoptotic protease-activating factor 1

CONJUGATE
Unconjugated

PURIFICATION
Apaf1 Antibody is affinity chromatography purified via peptide column.

HOST SPECIES
Rabbit

CLONALITY
Polyclonal

ISOTYPE
IgG

IMMUNOGEN
Apaf1 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human Apaf1. The sequences of the immunogenic peptide are identical between human and mouse.

TESTED APPLICATIONS
E, WB, IHC, IF

APPLICATIONS
Apaf1 antibody can be used for detection of Apaf1 by Western blot at 1 μg/mL. A 115 - 130 kDa band should be detected. Antibody can also be used for immunohistochemistry starting at 1 μg/mL. For immunofluorescence start at 10 μg/mL.

BUFFER
Apaf1 Antibody is supplied in PBS containing 0.02% sodium azide.

STORAGE CONDITIONS
Apaf1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

SPECIES REACTIVITY
Human, Mouse, Rat
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